job title:Senior Research Associate / Associate Scientist (i
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About Cyclarity Therapeutics
Cyclarity Therapeutics is a clinical-stage pharmaceutical company focused on developing therapies for atherosclerosis (heart disease) and other diseases of aging. We are seeking a motivated, detail-oriented Senior Research Associate/Associate Scientist (in vivo) to participate in the design and execution of in vivo, in vitro, and ex vivo studies to establish the safety and efficacy of compounds intended for clinical evaluation.
The successful candidate will contribute to preclinical drug discovery and development efforts in a collaborative, fast-paced environment.
**Location: Novato, California (on-site only; not a remote or hybrid position)**
Responsibilities
- Independently design and lead in vivo studies to advance drug discovery and development
- Perform rodent handling (mouse and rat)
- Conduct animal husbandry and routine vivarium upkeep (e.g., cage changes, husbandry, animal monitoring, etc.)
- Administer test compounds- IV, IP, SQ, IM injections, and oral gavage
- Perform blood collection techniques, including cardiac puncture, submandibular, saphenous vein, and retro-orbital methods
- Conduct necropsies, including organ removal, examination, and fixation for histological analysis=-
- Maintain rigorous and accurate laboratory notebooks
- Prepare laboratory reagents and solutions
- Plan and execute pharmacokinetic studies for new drug candidates
- Plan and execute disease models, including study design, dosing, tissue collection, and data analysis
Requirements
- BS or MS degree in biochemistry, cell biology, or a related biomedical field with 2+ years of experience
- Extensive hands-on rodent (rat and mouse) handling experience is required
- Demonstrated track record (multiple years) of independent in vivo work
- Experience with pharmacokinetic studies (drug administration, collection of blood, and collection of urine)
- Experience running in vivo efficacy models of disease in rats and mice
Preferred experience:
- Experience in the following areas is desirable and will strengthen an application:
- Histological slide analysis using ImageJ, QuPath, or related software
- Fluorescence microscopy and imaging
- Experience working with cholesterol and other natural or oxidized sterols
- Knowledge in the following areas: cardiovascular, MASH/MAFLD, retinal disease (AMD), Alzheimer’s disease, and other diseases of aging
This position represents the opportunity to join a small, dynamic, interdisciplinary team and will require the following personality traits:
- Excellent interpersonal and organizational skills
- Strong written and verbal communication skills in a cross-disciplinary team environment
- Initiative and the ability to work independently while integrating into team workflows
- Strong analytical and problem-solving abilities
- A collegial, respectful, and inclusive approach to teamwork
- Focus, adaptability, and resilience in addressing unanticipated challenges and opportunities
Cyclarity Therapeutics offers competitive compensation packages including salary commensurate with experience, paid vacation and sick leave, health insurance benefits, and early equity opportunities. Relocation benefits will not be provided for this position. Further information on Cyclarity Therapeutics can be found at www.cyclaritytx.com. Cyclarity Therapeutics is an equal opportunity employer.
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