About Novartis Institute of Biomedical Research:
At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.
NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology Disease Area and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.
About MAP:
the MAP (Metabolism and Pharmacokinetics) department is responsible for supporting drug discovery efforts by swiftly delivering a thorough understanding of the pharmacokinetics and metabolic fate of novel chemical entities, rapidly characterizing the ADME properties of medicinal chemistry compounds, and assessing PK/PD relationships of drug development candidates. The department supports all aspects of metabolism and pharmacokinetics via in vitro, in silico, ex vivo and in vivo studies to ensure delivery of drug like quality candidates for pre-clinical development.
About the position:
The candidate will be responsible for supporting and optimizing a suite of in vitro drug metabolism assays such as metabolic clearance, reversible or time-dependent CYP inhibitions, reaction phenotyping studies, CYP induction, plasma protein binding and other transporter assays. He or she will be dedicated to the daily operation of the existing ADME profiling assays, including microsomal or hepatocyte incubations, LCMS method development and LCMSMS sample analysis, with the agreed throughput, and interpretation of the data. Other responsibilities will include the maintenance and/or trouble-shooting of a number of automation systems in the lab. The candidate may initiate, lead or participate in the development of new ADME assays.
Qualifications:
Bachelors degree with at least 5 years or a Masters with at least 2 yrs in drug metabolism/transporter, pharmaceutics, analytical or related fields, preferable in the biotechnology or pharmaceutical industry.
A good understanding of underlying principles of cell culture, in vitro enzymology, and analytical chemistry is essential.
Strong skills in bioanalysis, lab automation, data management.
A good working knowledge of application software in lab automation (robot and plate reader).
Expertise in working with high-throughput in vitro ADME profiling assays is highly preferred.
Demonstrated skills in bringing projects to completion within specified timelines.
Strong written and verbal communication skills are essential, along with the ability to work effectively in teams.
Knowledge and experience in using Excel for data entry and analysis is required.
Experience with the use of automation tools in sample preparation is highly desirable.
Postdoctoral Program at NIBR
Our Presidential Postdoctoral Fellowship program provides talented scientists with a unique opportunity to perform high-quality research in an environment with the resources of a large pharmaceutical company. Each year, innovative scientists from academia are selected to become fellows and collaborate with leading pharmaceutical discovery scientists pursuing multidisciplinary research projects. Together, they apply their expertise to discovering new medicines that will help patients lead healthier lives. For more information about the Postdoctoral Program and to apply, please visit the Career section of www.nibr.com.
In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits.
Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V.
To apply, please use the link below:
http://appclix.postmasterlx.com/track.html?pid=ff80808124da912a0124daaf8bcf00ba&source=clsanfran
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